Medical Topic for Oswald
I just picked up his medication. Enronflocacin 22.7mg. She told me to crush about 1/2 a tablet into some food and syringe it to him every 12 hours
- Sef
- I dissent.
So, he weighs around 1.1kg. Half of a 22.7mg tablet would be 11.35 mg, which is a pretty high dose for his weight. With a standard range of roughly 2.5-10.0 mg/kg, a middle-of-the-road dose for his weight would be closer to 6.87mg. I think I'd be more inclined to quarter the tablet instead of cutting it in half, at least to start with to make sure it is well-tolerated. Just my opinion.
Ok I had given him the half already but I will keep an eye on him and keep that in mind
- Lynx
- Celebrate!!!
Here you go! Note the dangerous meds listed. Not prescribed, thankfully.
Culture Results: Status: FINAL
Isolate 1: Leclercia adecarboxylata - >100,000 CFU per ml
Generated by VetConnect® PLUS December 11, 2019 06:13 PM Page 3 of 4
DATE OF RESULT: 12/6/19 LAB ID: 7802569839
Microbiology (continued)
Isolate 2: Acinetobacter sp. - >100,000 CFU per ml
This isolate is considered an environmental or commensal organism, unlikely to be pathogenic in urine.
Therefore, susceptibility testing was not performed.
Isolate 1 MIC Isolate 2 MIC
Amoxicillin S <=2 N/I
Amoxicillin-Clavulanic Acid S <=2 N/I
Cephalexin S <=4 N/I
Cefpodoxime S 0.5 N/I
Cefovecin S <=0.5 N/I
Ceftazidime S <=0.12 N/I
Ceftiofur S <=1 N/I
Imipenem S <=0.25 N/I
Amikacin S <=2 N/I
Gentamicin S <=1 N/I
Ciprofloxacin S <=0.06 N/I
Enrofloxacin S <=0.12 N/I
Marbofloxacin S <=0.5 N/I
Doxycycline S 1 N/I
Nitrofurantoin S <=16 N/I
Chloramphenicol S <=2 N/I
Trimethoprim/Sulphate S <=20 N/I
Cefotaxime S N/I
**INTERPRETATION KEY for Antibiotic Susceptibility Results (when performed)**
S = Sensitive. Organism is inhibited by usual recommended dose.
I = Intermediate. Organism is inhibited only by the maximum recommended dose.
R = Resistant. Organism is resistant to the maximum recommended dose.
These standards have been established by the Clinical and Laboratory Standards Institute (CLSI).
TF = To Follow. Susceptibility testing for this antibiotic is performed by Kirby-Bauer and results will follow shortly.
N/I (not indicated) will be reported and/or MIC data may be left blank and not reported if:
a) the growth requirements of the organism require the sensitivity testing to be performed by another method
b) interpretive criteria are not available from CLSI (in this case, recommended antibiotics will be reported based on clinical efficacy studies)
c) certain antibiotics are not available due to limitations of our commercial laboratory system; or
d/ the drug is known to be clinically ineffective against the organism regardless of in vitro results
If "N/I" is listed for ALL antibiotics for a specific isolate, susceptibility testing was not performed for that organism. Please refer to the comment associated with the organism for recommendations if applicable.
For more information on Minimum Inhibitory Concentration (MIC) please see the "Microbiology Guide to Interpreting Minimum Inhibitory Concentration (MIC)" section of the IDEXX Reference Laboratories Directory of Services or visit www.idexx.com/MIC.
Sample appearance:
serum received unseparated or partially separated from cells.
Generated by VetConnect® PLUS December 11, 2019 06:13 PM
Culture Results: Status: FINAL
Isolate 1: Leclercia adecarboxylata - >100,000 CFU per ml
Generated by VetConnect® PLUS December 11, 2019 06:13 PM Page 3 of 4
DATE OF RESULT: 12/6/19 LAB ID: 7802569839
Microbiology (continued)
Isolate 2: Acinetobacter sp. - >100,000 CFU per ml
This isolate is considered an environmental or commensal organism, unlikely to be pathogenic in urine.
Therefore, susceptibility testing was not performed.
Isolate 1 MIC Isolate 2 MIC
Amoxicillin S <=2 N/I
Amoxicillin-Clavulanic Acid S <=2 N/I
Cephalexin S <=4 N/I
Cefpodoxime S 0.5 N/I
Cefovecin S <=0.5 N/I
Ceftazidime S <=0.12 N/I
Ceftiofur S <=1 N/I
Imipenem S <=0.25 N/I
Amikacin S <=2 N/I
Gentamicin S <=1 N/I
Ciprofloxacin S <=0.06 N/I
Enrofloxacin S <=0.12 N/I
Marbofloxacin S <=0.5 N/I
Doxycycline S 1 N/I
Nitrofurantoin S <=16 N/I
Chloramphenicol S <=2 N/I
Trimethoprim/Sulphate S <=20 N/I
Cefotaxime S N/I
**INTERPRETATION KEY for Antibiotic Susceptibility Results (when performed)**
S = Sensitive. Organism is inhibited by usual recommended dose.
I = Intermediate. Organism is inhibited only by the maximum recommended dose.
R = Resistant. Organism is resistant to the maximum recommended dose.
These standards have been established by the Clinical and Laboratory Standards Institute (CLSI).
TF = To Follow. Susceptibility testing for this antibiotic is performed by Kirby-Bauer and results will follow shortly.
N/I (not indicated) will be reported and/or MIC data may be left blank and not reported if:
a) the growth requirements of the organism require the sensitivity testing to be performed by another method
b) interpretive criteria are not available from CLSI (in this case, recommended antibiotics will be reported based on clinical efficacy studies)
c) certain antibiotics are not available due to limitations of our commercial laboratory system; or
d/ the drug is known to be clinically ineffective against the organism regardless of in vitro results
If "N/I" is listed for ALL antibiotics for a specific isolate, susceptibility testing was not performed for that organism. Please refer to the comment associated with the organism for recommendations if applicable.
For more information on Minimum Inhibitory Concentration (MIC) please see the "Microbiology Guide to Interpreting Minimum Inhibitory Concentration (MIC)" section of the IDEXX Reference Laboratories Directory of Services or visit www.idexx.com/MIC.
Sample appearance:
serum received unseparated or partially separated from cells.
Generated by VetConnect® PLUS December 11, 2019 06:13 PM
- Sef
- I dissent.
I'm not sure I understand the culture results. To this layperson's eye, it looks like that first "isolate" (Leclercia adecarboxylata) has sensitivity to all of those antibiotics -- including Bactrim:
Trimethoprim/Sulphate S <=20 N/I
Also, and even more confusing, I have not been able to find any literature on Leclercia adecarboxylata in guinea pigs or rabbits. Zilch. It doesn't even sound like it's very common in general. Did your vet remark on that at all?
Trimethoprim/Sulphate S <=20 N/I
Also, and even more confusing, I have not been able to find any literature on Leclercia adecarboxylata in guinea pigs or rabbits. Zilch. It doesn't even sound like it's very common in general. Did your vet remark on that at all?
https://www.vumicro.com/vumie/help/VUMI ... xylata.htmIt has been found only rarely in the environment or clinical isolates, and evidence of its involvement in causing disease is questioned.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544061/Leclercia adecarboxylata is a rare gram-negative rod of the Enterobacteriaceae family that has been isolated from water and infrequently reported in the literature.
I don’t recall her mentioning that. It’s been about two hours since I gave him his dosage and he seems good he’s eating his hay and veggies and also gave him the benebac. Will check on him again after work
Woke up this morning and no poops, found a few bits here and there. He ate his veggies last night but not much hay. I gave him so metoclopramide to see if that would help. While I was feeding him some CC he pooped on the towel but they weren’t well formed, I’m thinking maybe more benebac to counteract the antibiotic?
- Sef
- I dissent.
I would. I'm a bigger fan of just plain acidophilus, which you can mix with the Critical Care. We generally recommend probiotics at least an hour before or after giving an antibiotic, under the theory that it helps keep the "good" bacteria in the probiotic from getting wiped out by the antibiotic.
I'd contact the vet, but personally I'd be inclined to discontinue the Enrofloxacin. It doesn't sound like he is tolerating it very well.
I'd contact the vet, but personally I'd be inclined to discontinue the Enrofloxacin. It doesn't sound like he is tolerating it very well.